Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28961017 | 0.79 | CA1 (0.58) | CA1CA2CA12CA9LMNA | |
| SCHEMBL6496816 | 0.79 | CA1 (0.58) | CA1CA2CA12CA9LMNA | |
| SCHEMBL2776254 | 0.79 | CA1 (0.58) | CA1CA2CA12CA9LMNA | |
| SCHEMBL2777400 | 0.79 | CA1 (0.58) | CA1CA2CA12CA9LMNA | |
| SCHEMBL30070404 | 0.79 | CA1 (0.58) | CA1CA2CA12CA9LMNA | |
| SCHEMBL6505477 | 0.79 | CA1 (0.58) | CA1CA2CA12CA9LMNA | |
| SCHEMBL5184948 | 0.78 | SHMT2 (0.61) | CA1CA2CA12CA9LMNA | |
| SCHEMBL17350895 | 0.73 | CA1 (0.57) | CA1CA2CA12CA9LMNA | |
| SCHEMBL30070366 | 0.73 | CA12 (0.51) | CA1CA2CA12CA9LMNA | |
| SCHEMBL28960469 | 0.73 | CA12 (0.51) | CA1CA2CA12CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894043-B1 | Benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-05-17 | — | — | US | disclosed |
| CN-1162414-C | Benzothiadiazine derivs., preparation method and pharmaceutical compositions contg. same | ɪά��ʵ���� | 2004-08-18 | — | — | CN | disclosed |
| EP-1233953-B1 | NOVEL BENZOTHIADIAZINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2003-05-14 | — | — | EP | disclosed |
| CN-1402717-A | Benzothiadiazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-12 | — | — | CN | disclosed |