Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11097294 | 0.89 | GRIN2B (0.54) | GRIN2BSMN1; SMN2GRIN1GRIN2DGRIN3B | |
| SCHEMBL26985819 | 0.83 | MIF (0.53) | GRIN2BOPRK1GRIN1ENPP2DRD2 | |
| SCHEMBL31506291 | 0.83 | MIF (0.53) | GRIN2BOPRK1GRIN1ENPP2DRD2 | |
| SCHEMBL5075641 | 0.82 | GRIN2B (0.63) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL11094429 | 0.78 | GRIN2B (0.57) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL25484737 | 0.77 | CYP1A2 (0.57) | GRIN2BGRIN1CYP1A2CYP3A4CA12 | |
| SCHEMBL19745518 | 0.77 | GRIN2B (0.61) | GRIN2BGRIN1TAAR1KMT2ALMNA | |
| SCHEMBL23521033 | 0.76 | GRIN2B (0.74) | GRIN2BSMN1; SMN2GRIN1ENPP2GRIN2D | |
| SCHEMBL30389572 | 0.75 | GRIN2B (0.53) | GRIN2BGRIN1CYP1A2KMT2AMAPT | |
| SCHEMBL14587410 | 0.74 | GRIN2B (0.44) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884890-B2 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-04-26 | — | — | US | disclosed |