Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.53 |
| ▸ | NOS2 | P35228 | 3/20 | 0.46 |
| ▸ | NOS1 | P29475 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5075641 | 0.89 | GRIN2B (0.63) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL6495653 | 0.89 | GRIN2B (0.49) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL11094429 | 0.85 | GRIN2B (0.57) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL19745518 | 0.83 | GRIN2B (0.61) | GRIN2BGRIN1MEN1KMT2A | |
| SCHEMBL30389572 | 0.81 | GRIN2B (0.53) | GRIN2BGRIN1CYP1A2MEN1KMT2A | |
| SCHEMBL14587410 | 0.80 | GRIN2B (0.44) | GRIN2BGRIN1HTR3EHTR3BHTR3A | |
| SCHEMBL8544952 | 0.79 | GRIN2B (0.67) | GRIN2BGRIN1NOS2RAB9A | |
| SCHEMBL8548012 | 0.79 | SCN2A (0.55) | GRIN2BGRIN1NOS2ALDH1A1RAB9A | |
| SCHEMBL10692194 | 0.78 | GRIN2B (0.50) | GRIN2BGRIN1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL7076954 | 0.76 | GRIN2B (0.59) | GRIN2BGRIN1NOS2SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448776-A | Method of using certain substituted aliphatic secondary amines or their salts for easing breathing | BUCHER KARL (CH) | 1984-05-15 | — | — | US | disclosed |
| EP-0058373-A1 | Substituted aliphatic secondary amines and their salts, pharmaceutical compositions containing them and their use | CIBA-GEIGY AG (CH) | 1982-08-25 | — | — | EP | disclosed |