Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 17/20 | 0.68 |
| ▸ | ITGB2 | P05107 | 12/20 | 0.68 |
| ▸ | ICAM1 | P05362 | 12/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495878 | 1.00 | ITGAL (0.68) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL8298709 | 0.91 | ITGAL (0.57) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6820886 | 0.91 | ITGAL (0.77) | ITGALITGB2ICAM1 | |
| SCHEMBL8298631 | 0.90 | ITGAL (0.56) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6500029 | 0.88 | ITGAL (0.54) | ITGALITGB2ICAM1MAPTL3MBTL1 | |
| SCHEMBL6500024 | 0.88 | ITGAL (0.54) | ITGALITGB2ICAM1MAPTL3MBTL1 | |
| SCHEMBL6496997 | 0.85 | KDM4E (0.59) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6496998 | 0.85 | KDM4E (0.59) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL8297133 | 0.85 | ITGAL (0.57) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6496790 | 0.85 | ITGAL (0.57) | ITGALITGB2ICAM1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |