Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | JAK3 | P52333 | 9/20 | 0.52 |
| ▸ | BTK | Q06187 | 6/20 | 0.49 |
| ▸ | ITK | Q08881 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TTK | P33981 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6490706 | 0.92 | ERBB2 (0.66) | ERBB2EGFRJAK3BTKITK | |
| SCHEMBL6483467 | 0.86 | ERBB2 (0.58) | ERBB2EGFRJAK3BTKITK | |
| SCHEMBL6496347 | 0.83 | ERBB2 (0.55) | ERBB2EGFRJAK3BTKITK | |
| SCHEMBL6482765 | 0.81 | JAK3 (0.57) | EGFRJAK3BTKITKSRC | |
| SCHEMBL6497399 | 0.79 | BTK (0.58) | ERBB2EGFRJAK3BTKITK | |
| SCHEMBL6492634 | 0.79 | EGFR (0.54) | ERBB2EGFRJAK3BTKJAK2 | |
| SCHEMBL6484938 | 0.79 | ERBB2 (0.54) | ERBB2EGFRJAK3BTKITK | |
| SCHEMBL23902645 | 0.79 | ERBB2 (0.60) | ERBB2EGFR | |
| SCHEMBL30241481 | 0.79 | ERBB2 (0.60) | ERBB2EGFR | |
| SCHEMBL6492412 | 0.78 | ERBB2 (0.67) | ERBB2EGFRJAK3BTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881737-B2 | Substituted triazinyl acrylamide derivatives and methods of use | AMGEN INC. (US) | 2005-04-19 | — | — | US | claimed |
| EP-1390354-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | Amgen Inc. (US) | 2004-02-25 | — | — | EP | claimed |
| US-20030139416-A1 | Substituted triazinyl acrylamide derivatives and methods of use | AMGEN INC. | 2003-07-24 | — | — | US | claimed |
| WO-2002083653-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | claimed |
| US-6881737-B2 | Substituted triazinyl acrylamide derivatives and methods of use | AMGEN INC. (US) | 2005-04-19 | — | — | US | disclosed |
| US-20030139416-A1 | Substituted triazinyl acrylamide derivatives and methods of use | AMGEN INC. | 2003-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139416-A1 | Substituted triazinyl acrylamide derivatives and methods of use | PKD1, PKD2, GLS | ERBB2 440/4885EGFR 228/4885JAK3 2043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.