Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | GLS | O94925 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11022943 | 0.85 | HDAC1 (0.65) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL10154070 | 0.85 | POLB (0.60) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL31249652 | 0.85 | SMN1; SMN2 (0.61) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL378705 | 0.85 | SMN1; SMN2 (0.61) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL968090 | 0.84 | POLB (0.59) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL15831226 | 0.83 | POLB (0.58) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2748652 | 0.81 | POLB (0.56) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21980986 | 0.81 | USP2 (0.59) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4071390 | 0.81 | CTBP2 (0.64) | POLBUSP2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5103284 | 0.80 | USP2 (0.84) | POLBUSP2ALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |