Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL6500606 | 0.82 | KMT2A (0.48) | RPS6KA3ADORA1ADORA2AKMT2AMEN1 | |
| SCHEMBL4400611 | 0.78 | TNIK (0.38) | RPS6KA3ADORA1ADORA2AKMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL6529235 | 0.77 | MAPKAPK2 (0.54) | RPS6KA3ADORA1ADORA2AKMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL4399088 | 0.77 | ADORA1 (0.48) | RPS6KA3ADORA1ADORA2ATP53MAPT | |
| Ammonia Solution, Strong SCHEMBL6527759 | 0.76 | MAPT (0.46) | RPS6KA3ADORA1ADORA2AKMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL4401603 | 0.76 | DYRK1A (0.47) | RPS6KA3ADORA1ADORA2AKMT2ADHFR | |
| SCHEMBL17426503 | 0.75 | PIK3CD (0.46) | KMT2AMEN1PIK3CD | |
| SCHEMBL1554173 | 0.75 | ADORA1 (0.70) | RPS6KA3ADORA1ADORA2AKMT2A | |
| Ammonia Solution, Strong SCHEMBL6500596 | 0.75 | QPCT (0.46) | RPS6KA3ADORA1ADORA2AKMT2ATP53 | |
| Ammonia Solution, Strong SCHEMBL4396798 | 0.74 | ADORA1 (0.42) | RPS6KA3ADORA1ADORA2AKMT2ADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004125-A1 | Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors) | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004125-A1 | Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors) | GSK3B, GSK3A, GSKIP | RPS6KA3 33/4885ADORA1 1486/4885ADORA2A 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.