Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.37 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6486763 | 0.90 | HDAC1 (0.43) | HDAC6HDAC1USP30CHEK1TRPV1 | |
| SCHEMBL6500752 | 0.90 | USP30 (0.52) | HDAC6HDAC1USP30DGAT1 | |
| SCHEMBL6489240 | 0.89 | USP30 (0.43) | HDAC6HDAC1USP30CHEK1DGAT1 | |
| SCHEMBL6499660 | 0.89 | USP30 (0.43) | HDAC6HDAC1USP30DGAT1 | |
| SCHEMBL6491679 | 0.88 | USP30 (0.43) | USP30CHEK1CDK2AP1DGAT1GRM5 | |
| SCHEMBL6497171 | 0.88 | HDAC1 (0.46) | HDAC6HDAC1USP30DGAT1GRM5 | |
| SCHEMBL6487221 | 0.85 | HDAC6 (0.49) | HDAC6HDAC1USP30CHEK1DGAT1 | |
| SCHEMBL6490517 | 0.85 | NQO2 (0.44) | USP30CHEK1DGAT1NPC1RAB9A | |
| SCHEMBL6491156 | 0.84 | USP30 (0.41) | HDAC6HDAC1USP30CHEK1CDK2AP1 | |
| SCHEMBL6490039 | 0.84 | MAPK11 (0.47) | HDAC1CHEK1CDK2AP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | claimed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | claimed |
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | MALT1, WFS1, NR5A1 | HDAC6 1069/4885HDAC1 467/4885USP30 3442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.