Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 9/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 4/20 | 0.54 |
| ▸ | PPARD | Q03181 | 4/20 | 0.54 |
| ▸ | PPARA | Q07869 | 4/20 | 0.54 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497637 | 1.00 | ESRRA (0.61) | ESRRACYP3A4PPARGPPARDPPARA | |
| SCHEMBL6497480 | 0.89 | ESRRA (0.61) | ESRRACYP3A4PPARGPPARDPPARA | |
| SCHEMBL6497485 | 0.89 | ESRRA (0.61) | ESRRACYP3A4PPARGPPARDPPARA | |
| SCHEMBL7458048 | 0.84 | ESRRA (0.62) | ESRRACYP3A4PPARGPPARDPPARA | |
| SCHEMBL7458053 | 0.84 | ESRRA (0.62) | ESRRACYP3A4PPARGPPARDPPARA | |
| SCHEMBL6495372 | 0.83 | PPARD (0.64) | PPARGPPARDPPARA | |
| SCHEMBL6236808 | 0.79 | ESRRA (0.60) | ESRRACYP3A4PPARGPPARAFOXM1 | |
| SCHEMBL6236807 | 0.79 | ESRRA (0.60) | ESRRACYP3A4PPARGPPARAFOXM1 | |
| SCHEMBL6498584 | 0.77 | PIM1 (0.57) | ESRRACYP3A4PIM1PIM2PDE4B | |
| SCHEMBL6502439 | 0.77 | PPARD (0.61) | PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |