Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.62 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 8/20 | 0.42 |
| ▸ | HTR2B | P41595 | 8/20 | 0.42 |
| ▸ | HTR2C | P28335 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135009 | 0.96 | C5AR1 (0.60) | C5AR1F2RHTR2AHTR2BHTR2C | |
| SCHEMBL1913065 | 0.93 | C5AR1 (0.60) | C5AR1F2RHTR2AHTR2BHTR2C | |
| SCHEMBL4764278 | 0.92 | C5AR1 (0.58) | C5AR1F2RHTR2AHTR2BHTR2C | |
| SCHEMBL5136808 | 0.91 | C5AR1 (0.53) | C5AR1F2RHTR2AHTR2BHTR2C | |
| SCHEMBL649947 | 0.90 | C5AR1 (0.65) | C5AR1HTR2AHTR2BHTR2CSMN1; SMN2 | |
| SCHEMBL4766754 | 0.90 | C5AR1 (0.57) | C5AR1F2RHTR2AHTR2BHTR2C | |
| SCHEMBL4767016 | 0.89 | C5AR1 (0.75) | C5AR1F2RSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL652149 | 0.88 | C5AR1 (0.64) | C5AR1F2RSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL651406 | 0.88 | C5AR1 (0.63) | C5AR1SMN1; SMN2LMNAL3MBTL1TP53 | |
| SCHEMBL5136938 | 0.88 | C5AR1 (0.66) | C5AR1F2RHTR2AHTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |