Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.53 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 9/20 | 0.37 |
| ▸ | HTR2C | P28335 | 8/20 | 0.37 |
| ▸ | HTR2A | P28223 | 8/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135009 | 0.95 | C5AR1 (0.60) | C5AR1F2RHTR2BHTR2CHTR2A | |
| SCHEMBL649820 | 0.91 | C5AR1 (0.62) | C5AR1F2RHTR2BHTR2CHTR2A | |
| SCHEMBL5135936 | 0.89 | C5AR1 (0.63) | C5AR1LMNASMN1; SMN2L3MBTL1TSHR | |
| SCHEMBL4766754 | 0.89 | C5AR1 (0.57) | C5AR1F2RHTR2BHTR2CHTR2A | |
| SCHEMBL5135904 | 0.88 | C5AR1 (0.56) | C5AR1F2RTP53LMNASMN1; SMN2 | |
| SCHEMBL5071329 | 0.87 | C5AR1 (0.60) | C5AR1TP53LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL648955 | 0.86 | C5AR1 (0.58) | C5AR1OPRM1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL5073846 | 0.86 | C5AR1 (0.58) | C5AR1F2RLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL5135734 | 0.86 | C5AR1 (0.63) | C5AR1F2RLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL5136554 | 0.86 | C5AR1 (0.58) | C5AR1F2RLMNASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |