Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 7/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 5/20 | 0.51 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6498439 | 1.00 | ITGAL (0.51) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6504723 | 0.93 | ITGAL (0.54) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6504728 | 0.93 | ITGAL (0.54) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6502814 | 0.92 | NPC1 (0.46) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6502822 | 0.92 | NPC1 (0.46) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6497407 | 0.88 | KDM4E (0.46) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6497398 | 0.88 | KDM4E (0.46) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6496819 | 0.88 | KDM4E (0.48) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6496828 | 0.88 | KDM4E (0.48) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6506076 | 0.87 | KMT2A (0.54) | ITGALITGB2ICAM1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |