Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ITGAL | P20701 | 3/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506070 | 1.00 | KMT2A (0.54) | KMT2AKDM4ENPC1RAB9ANFE2L2 | |
| SCHEMBL6502814 | 0.91 | NPC1 (0.46) | KMT2AKDM4ENPC1RAB9AAPOBEC3A | |
| SCHEMBL6502822 | 0.91 | NPC1 (0.46) | KMT2AKDM4ENPC1RAB9AAPOBEC3A | |
| SCHEMBL6497407 | 0.88 | KDM4E (0.46) | KMT2AKDM4ENPC1RAB9AAPOBEC3A | |
| SCHEMBL6497398 | 0.88 | KDM4E (0.46) | KMT2AKDM4ENPC1RAB9AAPOBEC3A | |
| SCHEMBL6498445 | 0.87 | ITGAL (0.51) | KDM4ENPC1RAB9AAPOBEC3AAPOBEC3G | |
| SCHEMBL6498439 | 0.87 | ITGAL (0.51) | KDM4ENPC1RAB9AAPOBEC3AAPOBEC3G | |
| SCHEMBL6496819 | 0.85 | KDM4E (0.48) | KDM4ENPC1RAB9AAPOBEC3AAPOBEC3G | |
| SCHEMBL6496828 | 0.85 | KDM4E (0.48) | KDM4ENPC1RAB9AAPOBEC3AAPOBEC3G | |
| SCHEMBL6504728 | 0.83 | ITGAL (0.54) | KDM4ENPC1RAB9AAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |