Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 9/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 8/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 8/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6498498 | 1.00 | ITGAL (0.45) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL6498494 | 1.00 | ITGAL (0.45) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL6500234 | 0.93 | ITGAL (0.46) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL6500228 | 0.93 | ITGAL (0.46) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL6495913 | 0.92 | ITGAL (0.51) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL8297366 | 0.92 | ITGAL (0.51) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL6495908 | 0.92 | ITGAL (0.51) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL6497938 | 0.91 | ITGAL (0.45) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL6497930 | 0.91 | ITGAL (0.45) | ITGALITGB2ICAM1CAPN1MEN1 | |
| SCHEMBL6497925 | 0.91 | ITGAL (0.45) | ITGALITGB2ICAM1CAPN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |