Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 16/20 | 0.41 |
| ▸ | CA2 | P00918 | 16/20 | 0.41 |
| ▸ | CA9 | Q16790 | 15/20 | 0.41 |
| ▸ | CA12 | O43570 | 15/20 | 0.41 |
| ▸ | CA4 | P22748 | 14/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651801 | 0.91 | CRHR1 (0.42) | CRHR1MAPT | |
| SCHEMBL648462 | 0.91 | CA1 (0.42) | CA1CA2CA9CA12CA4 | |
| SCHEMBL651116 | 0.91 | CRHR1 (0.41) | CA1CA2CA12CA4CRHR1 | |
| SCHEMBL650406 | 0.91 | CRHR1 (0.41) | CRHR1MAPT | |
| SCHEMBL651662 | 0.91 | CRHR1 (0.37) | CA1CA2CA9CA12CA4 | |
| SCHEMBL649253 | 0.88 | SQLE (0.38) | CRHR1MAPT | |
| SCHEMBL1913045 | 0.88 | SMN1; SMN2 (0.41) | CRHR1MAPT | |
| SCHEMBL647849 | 0.86 | CRHR1 (0.38) | CRHR1MAPT | |
| SCHEMBL648054 | 0.86 | NR1H2 (0.39) | CRHR1 | |
| SCHEMBL651162 | 0.86 | CRHR1 (0.46) | CA1CA2CA12CA4CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |