Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 18/20 | 0.36 |
| ▸ | HTR2C | P28335 | 15/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 8/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6493141 | 0.79 | HTR2A (0.41) | HTR2AHTR2CHTR1ADRD4ADRA1A | |
| SCHEMBL6492716 | 0.73 | HTR2C (0.41) | HTR2AHTR2CHTR1ADRD4ADRA1A | |
| SCHEMBL6501085 | 0.73 | HTR2C (0.41) | HTR2AHTR2CHTR1ADRD4ADRA1A | |
| SCHEMBL5415823 | 0.71 | HTR2A (0.56) | HTR2AHTR2CHTR1ADRD4DRD2 | |
| SCHEMBL5415822 | 0.71 | HTR2A (0.56) | HTR2AHTR2CHTR1ADRD4DRD2 | |
| SCHEMBL5421689 | 0.70 | CCR3 (0.54) | HTR2AHTR2CHTR1ADRD4SLC6A4 | |
| SCHEMBL5421686 | 0.70 | CCR3 (0.54) | HTR2AHTR2CHTR1ADRD4SLC6A4 | |
| SCHEMBL5415535 | 0.70 | HTR2A (0.56) | HTR2AHTR2CHTR1ADRD4DRD2 | |
| SCHEMBL4555380 | 0.70 | HTR2A (0.64) | HTR2AHTR2CHTR1ADRD4ADRA1A | |
| SCHEMBL3311603 | 0.70 | HTR2A (0.64) | HTR2AHTR2CHTR1ADRD4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849619-B2 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-01 | — | — | US | disclosed |