Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.41 |
| ▸ | HTR2A | P28223 | 11/20 | 0.41 |
| ▸ | CCR3 | P51677 | 8/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492716 | 1.00 | HTR2C (0.41) | HTR2CHTR2ACCR3HTR1ADRD4 | |
| SCHEMBL5421689 | 0.84 | CCR3 (0.54) | HTR2CHTR2ACCR3HTR1ADRD4 | |
| SCHEMBL5421686 | 0.84 | CCR3 (0.54) | HTR2CHTR2ACCR3HTR1ADRD4 | |
| SCHEMBL6500634 | 0.84 | USP30 (0.45) | HTR2CHTR2ACCR3 | |
| SCHEMBL6500633 | 0.84 | USP30 (0.45) | HTR2CHTR2ACCR3 | |
| SCHEMBL5415823 | 0.82 | HTR2A (0.56) | HTR2CHTR2ACCR3HTR1ADRD4 | |
| SCHEMBL5415822 | 0.82 | HTR2A (0.56) | HTR2CHTR2ACCR3HTR1ADRD4 | |
| SCHEMBL6490580 | 0.82 | DRD2 (0.34) | HTR2CHTR2ACCR3DRD2 | |
| SCHEMBL6494306 | 0.82 | HTR2A (0.36) | HTR2CHTR2ADRD2 | |
| SCHEMBL6810428 | 0.82 | DRD2 (0.34) | HTR2CHTR2ACCR3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849619-B2 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| US-20040186094-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-09-23 | — | — | US | disclosed |
| US-6699852-B2 | ANTISEROTONIN AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-02 | — | — | US | disclosed |
| US-20020173503-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173503-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | HTR1A, HTR1B, HTR7 | HTR2C 11/4885HTR2A 21/4885CCR3 3424/4885 |
| US-20040186094-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | HTR1A, HTR1B, HTR7 | HTR2C 11/4885HTR2A 21/4885CCR3 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.