Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.50 |
| ▸ | ESR1 | P03372 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28549425 | 0.79 | ESR2 (0.51) | MAPTNPC1MEN1KMT2AESR2 | |
| SCHEMBL13209060 | 0.76 | GAA (0.50) | MAPTNPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15188908 | 0.76 | GAA (0.46) | MEN1KMT2AESR2ESR1GAA | |
| SCHEMBL29220708 | 0.76 | GAA (0.46) | MAPTKDM4ENPC1SMN1; SMN2LMNA | |
| SCHEMBL2784971 | 0.76 | GAA (0.46) | NPC1SMN1; SMN2MEN1KMT2AESR2 | |
| SCHEMBL15275530 | 0.76 | ESR2 (0.75) | MEN1KMT2AESR2ESR1GAA | |
| SCHEMBL13967956 | 0.76 | GAA (0.46) | MAPTNPC1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL6547698 | 0.76 | ESR1 (0.75) | MAPTNPC1SMN1; SMN2LMNAESR2 | |
| SCHEMBL11494065 | 0.75 | SMN1; SMN2 (0.45) | MAPTKDM4ENPC1SMN1; SMN2LMNA | |
| SCHEMBL18489521 | 0.75 | IDO1 (0.50) | MAPTKDM4ENPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1234693-C | Indazol compound for inhibiting protein kinase and medicine composition and their application | AGOURON PHARMA (US) | 2006-01-04 | — | — | CN | disclosed |
| US-6884890-B2 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-04-26 | — | — | US | disclosed |
| CN-1495171-A | Indazol compound for inhibiting protein kinase and medicine composition and their application | ������ҩ������˾ | 2004-05-12 | — | — | CN | disclosed |
| CN-1137884-C | Indazole compounds and pharmaceutical compositions that inhibit protein kinases and methods of use thereof | ������ҩ������˾ | 2004-02-11 | — | — | CN | disclosed |
| CN-1374950-A | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases and their use | AGOURON PHARMACETUICALS INC (US) | 2002-10-16 | — | — | CN | disclosed |