Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848641 | 0.84 | ESR2 (0.51) | GAANOS3NOS1NOS2ESR1 | |
| SCHEMBL28815005 | 0.83 | GAA (0.41) | GAANOS3NOS1NOS2ESR1 | |
| SCHEMBL18047920 | 0.82 | GAA (0.39) | GAANOS3NOS1NOS2ESR1 | |
| SCHEMBL7863180 | 0.79 | KMT2A (0.55) | GAANOS3NOS1NOS2MEN1 | |
| SCHEMBL11574278 | 0.79 | NOS3 (0.42) | NOS3NOS1NOS2ESR1ESR2 | |
| SCHEMBL6500347 | 0.76 | MAPT (0.52) | GAAESR1ESR2MEN1KMT2A | |
| SCHEMBL14499867 | 0.74 | GAA (0.42) | GAAESR1MEN1KMT2ANPC1 | |
| SCHEMBL13967956 | 0.74 | GAA (0.46) | GAAESR1ESR2MEN1KMT2A | |
| SCHEMBL15275530 | 0.74 | ESR2 (0.75) | GAAESR1ESR2MEN1KMT2A | |
| SCHEMBL13209060 | 0.74 | GAA (0.50) | GAAESR1ESR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170305937-A1 | PROCESS FOR THE PREPARATION OF AMINOARYL- AND AMINOHETEROARYL BORONIC ACIDS AND ESTERS | AMRI ITALY S.R.L. (IT) | 2017-10-26 | — | — | US | disclosed |
| US-20170305937-A1 | PROCESS FOR THE PREPARATION OF AMINOARYL- AND AMINOHETEROARYL BORONIC ACIDS AND ESTERS | AMRI ITALY S.R.L. (IT) | 2017-10-26 | — | — | US | disclosed |
| US-9738663-B2 | Process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters | EUTICALS S.P.A. (IT) | 2017-08-22 | — | — | US | disclosed |
| US-9738663-B2 | Process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters | EUTICALS S.P.A. (IT) | 2017-08-22 | — | — | US | disclosed |
| EP-2994473-B1 | PROCESS FOR THE PREPARATION OF AMINOARYL- AND AMINOHETEROARYL BORONIC ACIDS AND ESTERS | EUTICALS SPA (IT) | 2016-12-21 | — | — | EP | disclosed |
| US-20160075723-A1 | PROCESS FOR THE PREPARATION OF AMINOARYL- AND AMINOHETEROARYL BORONIC ACIDS AND ESTERS | AMRI ITALY S.R.L. (IT) | 2016-03-17 | — | — | US | disclosed |
| EP-1988095-B1 | Method for manufacturing aminoaryl or heteroaryl boronic acid and their derivatives | EUTICALS GMBH (DE) | 2016-01-27 | — | — | EP | disclosed |
| EP-2801577-A1 | Process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters | Euticals S.P.A. (IT) | 2014-11-12 | — | — | EP | disclosed |
| US-8648075-B2 | Substituted pyrido[2,3-b]pyrazines and an agrochemical composition thereof | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2014-02-11 | — | — | US | disclosed |
| US-20130137577-A1 | OXOPYRAZINE DERIVATIVE AND HERBICIDE | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2013-05-30 | — | — | US | disclosed |
| EP-2174934-B1 | OXOPYRAZINE DERIVATIVE AND HERBICIDE | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-20100197674-A1 | OXOPYRAZINE DERIVATIVE AND HERBICIDE | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| EP-2174934-A1 | OXOPYRAZINE DERIVATIVE AND HERBICIDE | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-1988095-A2 | Method for manufacturing aminoaryl or heteroaryl boronic acid and their derivatives | Archimica GmbH (DE) | 2008-11-05 | — | — | EP | disclosed |
| US-20080269523-A1 | Preparation of Aminoaryl and Aminoheteroaryl Boronic Acids and Derivatives Thereof | ARCHIMICA GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
| EP-1354887-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1097158-B1 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1354887-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | Massachusetts Insitute of Technology (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1097158-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002887-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269523-A1 | Preparation of Aminoaryl and Aminoheteroaryl Boronic Acids and Derivatives Thereof | BCAT1, BCAT2, AADAT | GAA 1490/4885NOS3 720/4885NOS1 1774/4885 |
| US-20130137577-A1 | OXOPYRAZINE DERIVATIVE AND HERBICIDE | CBR3, CBR1, DDT | GAA 3541/4885NOS3 125/4885NOS1 265/4885 |
| US-20170305937-A1 | PROCESS FOR THE PREPARATION OF AMINOARYL- AND AMINOHETEROARYL BORONIC ACIDS AND ESTERS | AADAT, BCAT2, BCAT1 | GAA 817/4885NOS3 2523/4885NOS1 2961/4885 |
| US-20160075723-A1 | PROCESS FOR THE PREPARATION OF AMINOARYL- AND AMINOHETEROARYL BORONIC ACIDS AND ESTERS | AADAT, BCAT2, BCAT1 | GAA 1756/4885NOS3 2077/4885NOS1 2700/4885 |
| US-20100197674-A1 | OXOPYRAZINE DERIVATIVE AND HERBICIDE | CBR3, CBR1, DDT | GAA 3541/4885NOS3 125/4885NOS1 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.