Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 10/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.37 |
| ▸ | HTR3B | O95264 | 5/20 | 0.37 |
| ▸ | HTR3A | P46098 | 5/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.37 |
| ▸ | ESRRG | P62508 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487891 | 0.87 | CHRNA7 (0.43) | CHRNA7PARP14HTR3EHTR3BHTR3A | |
| SCHEMBL6503138 | 0.85 | PARP14 (0.35) | PARP14TP53SMN1; SMN2HDAC6 | |
| SCHEMBL6488437 | 0.84 | CHRNA7 (0.38) | CHRNA7PARP14HTR3EHTR3BHTR3A | |
| SCHEMBL7223114 | 0.84 | CHRNA7 (0.40) | CHRNA7PARP14HTR3EHTR3BHTR3A | |
| SCHEMBL6488520 | 0.83 | CHRNA7 (0.44) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6485911 | 0.83 | ESRRG (0.49) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6485604 | 0.82 | CHRNA7 (0.45) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6485554 | 0.81 | CHRNA7 (0.46) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6496605 | 0.81 | HPGD (0.49) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6491668 | 0.81 | CHRNA7 (0.45) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | claimed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | claimed |
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | MALT1, WFS1, NR5A1 | CHRNA7 1097/4885PARP14 1038/4885HTR3E 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.