Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 3/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | GLS | O94925 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487702 | 0.89 | BRD4 (0.50) | PTPN11BRD4CCKBRNAMPTGLS | |
| SCHEMBL29289884 | 0.87 | BRD4 (0.53) | BRD4CCKBRNAMPTGLSAURKA | |
| SCHEMBL3507808 | 0.87 | BRD4 (0.53) | BRD4CCKBRNAMPTGLSAURKA | |
| SCHEMBL16193027 | 0.86 | BRD4 (0.52) | BRD4CCKBRNAMPTGLSAURKA | |
| SCHEMBL31709823 | 0.84 | BRD4 (0.54) | BRD4CCKBRNAMPTGLSAURKA | |
| SCHEMBL731764 | 0.84 | BRD4 (0.54) | BRD4CCKBRNAMPTGLSAURKA | |
| SCHEMBL5560988 | 0.84 | AURKA (0.52) | BRD4CCKBRNAMPTGLSAURKA | |
| SCHEMBL10209845 | 0.84 | AURKA (0.52) | BRD4CCKBRNAMPTGLSAURKA | |
| SCHEMBL27113148 | 0.84 | CA1 (0.51) | BRD4CCKBRNAMPTGLSAURKA | |
| SCHEMBL3509267 | 0.83 | BRD4 (0.52) | BRD4CCKBRNAMPTGLSAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |
| US-20020052513-A1 | Oxamide IMPDH inhibitors | HOFFMANN-LA ROCHE INC. | 2002-05-02 | — | — | US | disclosed |
| EP-1127883-A2 | Oxamides as IMPDH inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052513-A1 | Oxamide IMPDH inhibitors | IMPDH1, IMPDH2, IMPA1 | PTPN11 3448/4885BRD4 4308/4885GPR35 4326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.