Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 5/20 | 0.53 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509839 | 0.83 | MAPT (0.62) | TDP1MAPTMAPK1CYP2C9CYP2C19 | |
| SCHEMBL31693870 | 0.80 | MAPK1 (0.78) | MAPTMAPK1PKMCYP2C9CYP2C19 | |
| SCHEMBL4403596 | 0.80 | TDP1 (0.74) | TDP1MAPTMAPK1CYP2C9CYP2C19 | |
| SCHEMBL2559246 | 0.80 | TDP1 (0.63) | TDP1MAPTCYP2C9CYP2C19POLB | |
| SCHEMBL26870838 | 0.76 | MAPT (0.58) | MAPTMAPK1PKMCYP2C9CYP2C19 | |
| SCHEMBL14330888 | 0.76 | MAPT (0.53) | MAPTMAPK1PKMCYP2C9CYP2C19 | |
| SCHEMBL3435981 | 0.76 | MAPT (0.52) | MAPTMAPK1PKMCYP2C9CYP2C19 | |
| SCHEMBL14206434 | 0.74 | MAPT (0.48) | MAPTMAPK1PKMGPR174KMT2A | |
| SCHEMBL2039778 | 0.74 | TDP1 (0.74) | TDP1MAPTMAPK1CYP2C9CYP2C19 | |
| SCHEMBL2041681 | 0.74 | MAPT (0.79) | TDP1MAPTMAPK1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |