Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL1032214 | 1.00 | TDP1 (0.43) | TDP1TGFBR1TSHRPEPDOR51E2 | |
| Methacrylic Acid SCHEMBL476057 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 | |
| Methacrylic Acid SCHEMBL5463979 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 | |
| Methacrylic Acid SCHEMBL2219402 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 | |
| Methacrylic Acid SCHEMBL475891 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 | |
| Methacrylic Acid SCHEMBL2059838 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 | |
| Methacrylic Acid SCHEMBL5462229 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 | |
| Methacrylic Acid SCHEMBL18140227 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 | |
| Methacrylic Acid SCHEMBL4653322 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 | |
| Methacrylic Acid SCHEMBL18140953 | 0.91 | TDP1 (0.53) | TDP1TGFBR1TSHROR51E2TET2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129444-B2 | Self-adhesive dental materials | 3M ESPE AG (DE) | 2012-03-06 | — | — | US | disclosed |
| US-20060004122-A1 | Self-adhesive dental materials | 3M ESPE AG (DE) | 2006-01-05 | — | — | US | disclosed |
| US-6953535-B2 | Initiator system for acid dental formulations | 3M ESPE AG (DE) | 2005-10-11 | — | — | US | disclosed |
| US-20040110864-A1 | Self-adhesive dental materials | 3M ESPE AG (DE) | 2004-06-10 | — | — | US | disclosed |
| US-20040097613-A1 | Initiator system for acid dental formulations | 3M INNOVATIVE PROPERTIES COMPANY | 2004-05-20 | — | — | US | disclosed |