Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502171 | 1.00 | GAA (0.42) | GAAPTGER4PTGER2ROCK2ROCK1 | |
| SCHEMBL6203487 | 0.92 | GAA (0.43) | GAAPTGER4PTGER2ROCK2ROCK1 | |
| SCHEMBL6203493 | 0.92 | GAA (0.43) | GAAPTGER4PTGER2ROCK2ROCK1 | |
| SCHEMBL6203492 | 0.92 | GAA (0.43) | GAAPTGER4PTGER2ROCK2ROCK1 | |
| SCHEMBL6496760 | 0.91 | GAA (0.43) | GAAPTGER4PTGER2ROCK2ROCK1 | |
| SCHEMBL6496765 | 0.91 | GAA (0.43) | GAAPTGER4PTGER2ROCK2ROCK1 | |
| SCHEMBL6496338 | 0.90 | ACACB (0.39) | PTGER4PTGER2ROCK2 | |
| SCHEMBL6496343 | 0.90 | ACACB (0.39) | PTGER4PTGER2ROCK2 | |
| SCHEMBL6500808 | 0.89 | ROCK2 (0.40) | GAAPTGER4PTGER2ROCK2ROCK1 | |
| SCHEMBL6500810 | 0.89 | ROCK2 (0.40) | GAAPTGER4PTGER2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900210-B2 | Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-05-31 | — | — | US | disclosed |