Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.49 |
| ▸ | DBH | P09172 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390042 | 0.83 | SMN1; SMN2 (0.52) | POLBTHRBMAPK14DBHALDH1A1 | |
| SCHEMBL4384464 | 0.83 | MAPK14 (0.61) | POLBTHRBMAPK14DBHALDH1A1 | |
| Hydrochloric Acid SCHEMBL4376344 | 0.82 | MAPK14 (0.60) | POLBTHRBMAPK14DBHALDH1A1 | |
| SCHEMBL27621455 | 0.78 | POLB (0.53) | POLBTHRBMAPK14DBHALDH1A1 | |
| SCHEMBL4376920 | 0.77 | MAPK14 (0.77) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL4376099 | 0.76 | MAPK14 (0.76) | POLBTHRBMAPK14ALDH1A1KDM4E | |
| SCHEMBL4377801 | 0.75 | L3MBTL1 (0.49) | POLBTHRBMAPK14DBHALDH1A1 | |
| SCHEMBL4378463 | 0.74 | MAPK14 (0.64) | POLBTHRBMAPK14DBHALDH1A1 | |
| SCHEMBL4383504 | 0.74 | MAPK14 (0.77) | MAPK14 | |
| SCHEMBL1866365 | 0.72 | EGLN1 (0.69) | POLBTHRBMAPK14DBHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | POLB 1676/4885THRB 1529/4885MAPK14 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.