Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | QPCT | Q16769 | 1/20 | 0.47 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.47 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925217 | 0.78 | HPGDS (0.53) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL1196868 | 0.77 | HPGDS (0.51) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL1196872 | 0.77 | HPGDS (0.51) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL19936854 | 0.77 | HPGDS (0.51) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL3672494 | 0.77 | HPGDS (0.51) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL25395574 | 0.77 | HPGDS (0.51) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL2972635 | 0.77 | HPGDS (0.51) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL28098973 | 0.77 | HPGDS (0.51) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL1346083 | 0.76 | HPGDS (0.77) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL30741761 | 0.76 | HPGDS (0.50) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | claimed |
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |