Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31036179 | 0.92 | HSD17B10 (0.60) | MAPTHDAC1HDAC8HSD17B10TRPV1 | |
| SCHEMBL13652571 | 0.88 | MTNR1A (0.62) | ALDH1A1MAPTKDM4EPOLBGAA | |
| SCHEMBL6169205 | 0.86 | HPGD (0.63) | HPGDKDM4EPOLBGAAHDAC1 | |
| SCHEMBL9490321 | 0.85 | MTNR1A (0.60) | MAPTKDM4EHSD17B10 | |
| SCHEMBL30444962 | 0.83 | HDAC1 (0.61) | MAPTHDAC1HDAC8HSD17B10TRPV1 | |
| SCHEMBL1984009 | 0.83 | MAPT (0.56) | HPGDALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL4857939 | 0.83 | MAPT (0.56) | HPGDALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL761158 | 0.81 | KDM4E (0.61) | HPGDALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL1690856 | 0.81 | HPGD (0.71) | HPGDALDH1A1HDAC1HDAC8 | |
| SCHEMBL9002952 | 0.81 | HPGD (0.65) | HPGDALDH1A1MAPTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946468-B1 | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors | ZENECA LIMITED (GB) | 2005-09-20 | — | — | US | disclosed |