SCHEMBL6502732

SCHEMBL6502732

ICCc1ccc(-c2ccccc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.70
HPGD P15428 1/20 0.70
ALOX15 P16050 1/20 0.70
ALOX12 P18054 1/20 0.70
CASP1 P29466 1/20 0.70
HSD17B10 Q99714 1/20 0.70
FFAR1 O14842 1/20 0.56
TAAR1 Q96RJ0 2/20 0.54
KCNH2 Q12809 1/20 0.50
MMP12 P39900 5/20 0.48
IDO1 P14902 2/20 0.48
AGXT P21549 2/20 0.48
ABCC4 O15439 1/20 0.48
LMNA P02545 1/20 0.48
GAA P10253 1/20 0.48
TSHR P16473 1/20 0.48
PTGS1 P23219 1/20 0.48
HTT P42858 1/20 0.48
MMP13 P45452 4/20 0.47
MMP2 P08253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8622458 0.88 ALDH1A1 (0.54) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8619956 0.88 ALDH1A1 (0.54) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL4533203 0.86 ALDH1A1 (0.52) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8620569 0.84 HDAC2 (0.53) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL5551465 0.83 FFAR1 (0.60) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL172979 0.83
SCHEMBL5539870 0.82 FFAR1 (0.59) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL7365145 0.81 ALDH1A1 (0.65) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL4623627 0.81 TAAR1 (0.56) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL1262498 0.81 TAAR1 (0.56) ALDH1A1HSD17B10FFAR1TAAR1MMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3100731-A1 LIGAND-CYTOTOXICITY DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND USES THEREOF Shanghai Hengrui Pharmaceutical Co., Ltd. (CN) 2016-12-07 EP disclosed
US-7169817-B2 Bis-aromatic alkanols IRM LLC (BM) 2007-01-30 US disclosed
US-7169817-B2 Bis-aromatic alkanols IRM LLC (BM) 2007-01-30 US disclosed
WO-2005014525-A2 BI-ARYL COMPOUND HAVING IMMUNOSUPPRESSIVE ACTIVITY MITSUBISHI PHARMA CORPORATION (JP) 2005-02-17 WO disclosed
US-6297239-B1 Inhibitors of prenyl-protein transferase MERCK & CO., INC. 2001-10-02 US disclosed
EP-1021188-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2000-07-26 EP disclosed
EP-0771196-B1 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS LILLY CO ELI (US) 1999-12-08 EP disclosed
WO-1999017777-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-04-15 WO disclosed
US-5717109-A CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS ELI LILLY AND COMPANY (US) 1998-02-10 US disclosed
EP-0771196-A4 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS LILLY CO ELI (US) 1997-09-03 EP disclosed
EP-0771196-A1 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1997-05-07 EP disclosed
WO-1996007405-A1 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1996-03-14 WO disclosed