Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | CCR3 | P51677 | 2/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210324 | 0.95 | CYP2D6 (0.55) | CYP2D6HRH1CCR3CCR1DRD4 | |
| SCHEMBL6216008 | 0.93 | ABCB1 (0.47) | CYP2D6HRH1CCR3CCR1DRD4 | |
| SCHEMBL6215764 | 0.92 | CYP2D6 (0.51) | CYP2D6HRH1CCR3CCR1DRD4 | |
| SCHEMBL6212247 | 0.91 | HRH1 (0.57) | HRH1CCR3CCR1 | |
| SCHEMBL6211304 | 0.90 | CCR3 (0.44) | CYP2D6HRH1CCR3CCR1DRD4 | |
| SCHEMBL6212693 | 0.90 | HRH1 (0.51) | CYP2D6HRH1CCR3DRD4DRD2 | |
| SCHEMBL6214289 | 0.87 | DRD2 (0.52) | CYP2D6HRH1CCR3CCR1DRD4 | |
| SCHEMBL6212528 | 0.87 | CYP2D6 (0.47) | CYP2D6HRH1CCR3CCR1DRD4 | |
| SCHEMBL6214634 | 0.86 | ABCB1 (0.59) | HRH1CCR3CCR1DRD4DRD2 | |
| SCHEMBL6217490 | 0.85 | CYP2D6 (0.53) | CYP2D6CCR1DRD4SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951874-B2 | Compounds | ASTRAZENECA AB (SE) | 2005-10-04 | — | — | US | disclosed |
| CN-1458281-A | Coronary virus RNA interference preparation for severe acute respiratory syndrome pathogen | HUANQIU ZHONGJIA BIOLOG SCIENC (CN) | 2003-11-26 | — | — | CN | disclosed |
| CN-1426412-A | Novel compounds | ASTRAZENECA AB (SE) | 2003-06-25 | — | — | CN | disclosed |