Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 14/20 | 0.61 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.61 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.60 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.57 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.57 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.57 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.57 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.57 |
| ▸ | GPR183 | P32249 | 1/20 | 0.57 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502032 | 0.95 | SPHK2 (0.67) | S1PR1S1PR3SPHK2SPHK1S1PR4 | |
| SCHEMBL80477 | 0.91 | SPHK2 (0.72) | S1PR1S1PR3SPHK2SPHK1S1PR4 | |
| SCHEMBL6506538 | 0.90 | SPHK2 (0.60) | S1PR1S1PR3SPHK2SPHK1S1PR4 | |
| SCHEMBL6507624 | 0.90 | SPHK2 (0.60) | S1PR1S1PR3SPHK2SPHK1S1PR4 | |
| SCHEMBL6503026 | 0.82 | S1PR1 (0.65) | S1PR1S1PR3SPHK2SPHK1S1PR4 | |
| SCHEMBL6503023 | 0.81 | S1PR1 (0.91) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL6502901 | 0.80 | S1PR1 (0.88) | S1PR1S1PR3SPHK2SPHK1S1PR4 | |
| SCHEMBL6529926 | 0.78 | S1PR1 (0.91) | S1PR1S1PR3SPHK2SPHK1S1PR4 | |
| SCHEMBL5399738 | 0.78 | S1PR1 (0.91) | S1PR1S1PR3SPHK2SPHK1S1PR4 | |
| SCHEMBL6528485 | 0.78 | S1PR1 (0.91) | S1PR1S1PR3SPHK2SPHK1S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014525-A2 | BI-ARYL COMPOUND HAVING IMMUNOSUPPRESSIVE ACTIVITY | MITSUBISHI PHARMA CORPORATION (JP) | 2005-02-17 | — | — | WO | claimed |
| WO-2005014525-A2 | BI-ARYL COMPOUND HAVING IMMUNOSUPPRESSIVE ACTIVITY | MITSUBISHI PHARMA CORPORATION (JP) | 2005-02-17 | — | — | WO | disclosed |