Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471875 | 0.89 | ALDH1A1 (0.56) | ALDH1A1OPRK1LMNAPDE4APDE4B | |
| SCHEMBL2706645 | 0.82 | ALDH1A1 (0.60) | ALDH1A1OPRK1LMNAPDE4APDE4B | |
| SCHEMBL6471091 | 0.81 | ALDH1A1 (0.58) | ALDH1A1OPRK1LMNAPOLBGAA | |
| SCHEMBL6506511 | 0.78 | MAPK14 (0.51) | ALDH1A1OPRK1LMNAMAPTRAB9A | |
| SCHEMBL2707694 | 0.74 | ALDH1A1 (0.56) | ALDH1A1OPRK1LMNAPDE4APDE4B | |
| SCHEMBL14989717 | 0.72 | ALDH1A1 (0.51) | ALDH1A1OPRK1LMNAPDE4APDE4B | |
| SCHEMBL4509497 | 0.72 | ALDH1A1 (0.57) | ALDH1A1OPRK1LMNAPDE4APDE4B | |
| SCHEMBL4383585 | 0.72 | MAPT (0.46) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL4387429 | 0.72 | ALDH1A1 (0.47) | ALDH1A1LMNAMEN1KMT2AMITF | |
| SCHEMBL13603337 | 0.72 | MAPK14 (0.47) | ALDH1A1MAPK14ROCK2MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | ALDH1A1 741/4885OPRK1 282/4885LMNA 1884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.