Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 7/20 | 0.53 |
| ▸ | CA1 | P00915 | 7/20 | 0.53 |
| ▸ | CA2 | P00918 | 7/20 | 0.53 |
| ▸ | CA9 | Q16790 | 7/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21379858 | 0.81 | CA12 (0.56) | CA12CA1CA2CA9MAPK8 | |
| SCHEMBL6503780 | 0.81 | CA12 (0.53) | CA12CA1CA2CA9MAPK8 | |
| SCHEMBL5298479 | 0.81 | NPC1 (0.53) | MAPK8KMT2ANPC1RAB9AP2RX7 | |
| SCHEMBL30545016 | 0.81 | CA12 (0.56) | CA12CA1CA2CA9MAPK8 | |
| SCHEMBL16268539 | 0.78 | CA12 (0.56) | CA12CA1CA2CA9MAPK8 | |
| SCHEMBL28762298 | 0.78 | CA12 (0.70) | CA12CA1CA2CA9MAPK8 | |
| SCHEMBL1778391 | 0.77 | CA12 (0.47) | CA12CA1CA2CA9MAPK8 | |
| SCHEMBL1449282 | 0.77 | CA12 (0.47) | CA12CA1CA2CA9MAPK8 | |
| SCHEMBL3943414 | 0.77 | LMNA (0.54) | CA1CA2MAPK8KMT2ANPC1 | |
| SCHEMBL31042998 | 0.77 | KMT2A (0.51) | CA12CA1CA2CA9MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |