Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 10/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510233 | 0.82 | LGMN (0.59) | FFAR4KDM4EPDK2MAPTHTT | |
| SCHEMBL5800964 | 0.81 | NOTUM (0.83) | FFAR4NOTUMKDM4EUSP2HPGD | |
| SCHEMBL1573274 | 0.79 | NOTUM (0.83) | NOTUM | |
| SCHEMBL5798727 | 0.78 | NOTUM (0.59) | FFAR4NOTUMSMN1; SMN2MAPT | |
| SCHEMBL1222301 | 0.78 | NOTUM (0.79) | NOTUMKDM4ECYP2C19MAPTRAB9A | |
| SCHEMBL5799563 | 0.78 | NOTUM (0.58) | NOTUMKDM4EUSP2HPGDNPSR1 | |
| SCHEMBL5799166 | 0.78 | NOTUM (0.58) | NOTUMKDM4EPDK2CYP2C19 | |
| SCHEMBL5799181 | 0.78 | NOTUM (0.59) | NOTUMADAMTS5SMN1; SMN2USP2HPGD | |
| SCHEMBL6501087 | 0.77 | NOTUM (0.57) | NOTUMSMN1; SMN2KDM4EUSP2HPGD | |
| SCHEMBL6506958 | 0.77 | NOTUM (0.85) | NOTUMKDM4EUSP2HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |