Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.52 |
| ▸ | STS | P08842 | 7/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923396 | 0.87 | HPGD (0.54) | HPGDPTPN2PTPN1PTPN6STS | |
| SCHEMBL23674877 | 0.85 | HPGD (0.61) | HPGDPTPN2PTPN1PTPN6STS | |
| SCHEMBL2585461 | 0.83 | PTPN2 (0.49) | HPGDPTPN2PTPN1PTPN6STS | |
| SCHEMBL6106540 | 0.82 | HPGD (0.54) | HPGDPTPN2PTPN1PTPN6STS | |
| SCHEMBL7746749 | 0.82 | ITGB3 (0.56) | HPGDKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL20366042 | 0.81 | TSHR (0.50) | HPGDPTPN2PTPN1PTPN6STS | |
| SCHEMBL21184012 | 0.81 | HPGD (0.52) | HPGDPTPN2PTPN1PTPN6STS | |
| SCHEMBL12189222 | 0.80 | HPGD (0.51) | HPGDPTPN2PTPN1PTPN6STS | |
| SCHEMBL2146474 | 0.79 | HPGD (0.57) | HPGDPTPN2PTPN1PTPN6STS | |
| SCHEMBL3821259 | 0.78 | EPHX1 (0.54) | HPGDPTPN2PTPN1PTPN6RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |