Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 20/20 | 0.77 |
| ▸ | PPARG | P37231 | 17/20 | 0.77 |
| ▸ | PPARD | Q03181 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430239 | 0.88 | PPARA (0.77) | PPARAPPARGCYP2C9KCNH2 | |
| Muraglitazar SCHEMBL676469 | 0.87 | PPARA (1.00) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL13718146 | 0.87 | PPARA (0.93) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL5441887 | 0.86 | PPARG (0.60) | PPARAPPARGPPARD | |
| SCHEMBL5438454 | 0.86 | PPARA (0.73) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL5422265 | 0.85 | PPARG (0.76) | PPARAPPARGPPARD | |
| SCHEMBL13721992 | 0.84 | PPARA (0.87) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL5425806 | 0.84 | PPARA (0.79) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL13722049 | 0.84 | PPARA (0.93) | PPARAPPARGCYP2C9KCNH2 | |
| SCHEMBL5425800 | 0.84 | PPARA (0.78) | PPARAPPARGCYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049589-A2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA, DIABETES, OBESITY AND SIMILAR DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049589-A2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA, DIABETES, OBESITY AND SIMILAR DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2005-06-02 | — | — | WO | disclosed |