Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847908 | 0.81 | CRHR1 (0.64) | NPC1CRHR1EGLN2 | |
| SCHEMBL6497303 | 0.80 | NPC1 (0.49) | NPC1KDM4EEGLN2MAPT | |
| SCHEMBL6495917 | 0.80 | NPC1 (0.49) | NPC1KDM4ECRHR1EGLN2MAPT | |
| SCHEMBL6505513 | 0.79 | NPC1 (0.51) | NPC1KDM4ECRHR1EGLN2MAPT | |
| SCHEMBL6494394 | 0.78 | NPC1 (0.50) | NPC1KDM4ECRHR1EGLN2MAPT | |
| SCHEMBL6495922 | 0.78 | NPC1 (0.50) | NPC1KDM4ECRHR1EGLN2MAPT | |
| SCHEMBL6070559 | 0.77 | CRHR1 (0.55) | CRHR1DPP4 | |
| SCHEMBL6494387 | 0.77 | NPC1 (0.49) | NPC1KDM4ECRHR1EGLN2MAPT | |
| SCHEMBL6497711 | 0.77 | NPC1 (0.49) | NPC1KDM4ECRHR1EGLN2 | |
| SCHEMBL6505240 | 0.77 | NPC1 (0.46) | NPC1KDM4EEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958341-B2 | Pyrazolopyrimidines as CRF antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-10-25 | — | — | US | disclosed |