SCHEMBL6505819

SCHEMBL6505819

O=C(O)C(c1ccccc1)C(O)c1cccnc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.58
CYP2D6 P10635 1/20 0.53
CFTR P13569 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A4 P31645 1/20 0.52
SLC6A3 Q01959 1/20 0.52
GOPC Q9HD26 1/20 0.52
TBXAS1 P24557 1/20 0.47
KCNA5 P22460 3/20 0.46
KCNN4 O15554 2/20 0.46
GAA P10253 2/20 0.45
KDM4E B2RXH2 2/20 0.45
GRM8 O00222 1/20 0.45
GRM4 Q14833 1/20 0.45
LMNA P02545 3/20 0.43
ALDH1A1 P00352 1/20 0.43
APP P05067 1/20 0.43
HCAR3 P49019 1/20 0.43
HCAR2 Q8TDS4 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9592454 0.81 SMN1; SMN2 (0.70) SMN1; SMN2CYP2D6CFTRSLC6A2SLC6A4
SCHEMBL5178065 0.81 CYP2D6 (0.73) CYP2D6KDM4ELMNAALDH1A1MAPK1
SCHEMBL29975559 0.79 SMN1; SMN2 (0.53) SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL21853748 0.79 SMN1; SMN2 (0.53) SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL2450934 0.79 SMN1; SMN2 (0.53) SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL2450936 0.79 SMN1; SMN2 (0.53) SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL5929613 0.79 SMN1; SMN2 (0.53) SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL2684159 0.78 SMN1; SMN2 (0.60) SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL31404936 0.78 SMN1; SMN2 (0.60) SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL10170624 0.78 SMN1; SMN2 (0.60) SMN1; SMN2CFTRSLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005123727-A1 3-ARYL-3-HYDROXY- AND 3-ARYL-3-OXOPROPIONIC ACID ESTERS AS FUNGICIDES CROPSOLUTION, INC. (US) 2005-12-29 WO disclosed