SCHEMBL6505957

SCHEMBL6505957

Fc1cc2cccc(Br)c2[nH]1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.50
CA9 Q16790 2/20 0.50
NOS1 P29475 1/20 0.42
HRH4 Q9H3N8 2/20 0.41
DAO P14920 3/20 0.37
DDO Q99489 2/20 0.37
ENPP3 O14638 1/20 0.34
ENPP1 P22413 1/20 0.34
CYP2A6 P11509 1/20 0.32
DYRK1A Q13627 3/20 0.32
CDK9 P50750 2/20 0.32
DYRK2 Q92630 2/20 0.32
DYRK1B Q9Y463 2/20 0.32
NISCH Q9Y2I1 1/20 0.31
BACE1 P56817 1/20 0.31
KDM4E B2RXH2 1/20 0.30
HSD17B10 Q99714 1/20 0.30
PTGES O14684 1/20 0.30
MEN1 O00255 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21877855 0.78 CA12 (0.53) CA12CA9NOS1HRH4DAO
SCHEMBL17673224 0.77 CA12 (0.52) CA12CA9NOS1HRH4DAO
SCHEMBL28251365 0.75 DAO (0.53) CA12CA9NOS1HRH4DAO
SCHEMBL597517 0.75 CA12 (0.50) CA12CA9NOS1HRH4DAO
SCHEMBL28002630 0.75 HRH4 (0.41) CA12CA9HRH4DAODDO
SCHEMBL27096591 0.75 CA12 (0.46) CA12CA9NOS1HRH4DAO
SCHEMBL30774097 0.75 CA12 (0.46) CA12CA9NOS1HRH4DAO
SCHEMBL24630261 0.71 CA12 (0.46) CA12CA9NOS1HRH4DAO
SCHEMBL16835575 0.71 DHODH (0.55) CA12CA9NOS1HRH4KDM4E
SCHEMBL5675106 0.71 CA12 (0.46) CA12CA9NOS1HRH4DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002004440-A9 COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES BRISTOL MYERS SQUIBB CO (US) 2005-11-03 WO disclosed
EP-1299382-A4 COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES BRISTOL MYERS SQUIBB CO (US) 2004-02-11 EP disclosed
EP-1299382-A1 COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES BRISTOL-MYERS SQUIBB COMPANY (US) 2003-04-09 EP disclosed
WO-2002004440-A1 COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-01-17 WO disclosed