Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.53 |
| ▸ | FBP1 | P09467 | 4/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1419947 | 0.88 | FBP1 (0.67) | EGFRERBB2FBP1ERBB4 | |
| SCHEMBL1417820 | 0.87 | EGFR (0.64) | EGFRERBB2FBP1ERBB4KDR | |
| SCHEMBL1418255 | 0.85 | EGFR (0.81) | EGFRERBB2ERBB4KDRSRC | |
| SCHEMBL1418577 | 0.85 | EGFR (0.61) | EGFRERBB2FBP1ERBB4KDR | |
| SCHEMBL1418523 | 0.85 | EGFR (0.61) | EGFRERBB2FBP1ERBB4KDR | |
| SCHEMBL1418470 | 0.85 | EGFR (0.61) | EGFRERBB2FBP1ERBB4KDR | |
| SCHEMBL7839812 | 0.85 | EGFR (0.58) | EGFRERBB2FBP1ERBB4KDR | |
| SCHEMBL4226545 | 0.84 | FBP1 (0.67) | EGFRERBB2FBP1ERBB4KDR | |
| SCHEMBL4222304 | 0.84 | FBP1 (0.67) | EGFRERBB2FBP1ERBB4KDR | |
| SCHEMBL1417690 | 0.83 | EGFR (0.63) | EGFRERBB2KDRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |