Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 16/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 13/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 13/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499516 | 0.90 | ITGAL (0.45) | ITGALITGB2ICAM1LMNANPC1 | |
| SCHEMBL6497043 | 0.82 | ITGAL (0.49) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6504235 | 0.77 | ITGAL (0.50) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6497017 | 0.77 | ITGAL (0.49) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6504239 | 0.77 | ITGAL (0.48) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6495883 | 0.77 | ITGAL (0.68) | ITGALITGB2ICAM1ENPP2NPC1 | |
| SCHEMBL6495878 | 0.77 | ITGAL (0.68) | ITGALITGB2ICAM1ENPP2NPC1 | |
| SCHEMBL6498212 | 0.76 | ITGAL (0.52) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6497898 | 0.76 | ITGAL (0.52) | ITGALITGB2ICAM1NPC1RAB9A | |
| SCHEMBL6496790 | 0.75 | ITGAL (0.57) | ITGALITGB2ICAM1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |