Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | MDM4 | O15151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TGM2 | P21980 | 2/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506337 | 1.00 | SIRT2 (0.45) | SIRT2MDM4TP53TGM2ITGA4 | |
| SCHEMBL29679135 | 0.91 | MDM4 (0.51) | MDM4TP53TGM2ITGA4ITGB7 | |
| SCHEMBL6499392 | 0.91 | MDM4 (0.51) | MDM4TP53TGM2ITGA4ITGB7 | |
| SCHEMBL119871 | 0.91 | MDM4 (0.51) | MDM4TP53TGM2ITGA4ITGB7 | |
| SCHEMBL6499381 | 0.91 | MDM4 (0.51) | MDM4TP53TGM2ITGA4ITGB7 | |
| SCHEMBL15697341 | 0.85 | CTSB (0.49) | MDM4TP53CASP3 | |
| SCHEMBL17054211 | 0.82 | MDM4 (0.45) | MDM4TP53CASP3MDM2 | |
| SCHEMBL2977877 | 0.82 | ATM (0.53) | MDM4TP53CASP3 | |
| SCHEMBL12531899 | 0.82 | ATM (0.53) | MDM4TP53CASP3 | |
| SCHEMBL13743302 | 0.82 | ATM (0.53) | MDM4TP53CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |