SCHEMBL6506416

SCHEMBL6506416

O=c1c2nn(-c3ccccc3Cl)c(-c3ccc(Cl)cc3)c2cnn1CC(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 20/20 1.00
ADRB2 P07550 1/20 0.44
ADRA2A P08913 1/20 0.44
AGTR1 P30556 1/20 0.44
GLP1R P43220 1/20 0.44
CX3CR1 P49238 1/20 0.44
FFAR4 Q5NUL3 1/20 0.44
ADGRF1 Q5T601 1/20 0.44
GPR119 Q8TDV5 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6510594 0.85 CNR1 (0.74) CNR1
SCHEMBL4823932 0.82 CNR1 (1.00) CNR1
SCHEMBL6514552 0.78 CNR1 (0.63) CNR1
SCHEMBL763023 0.76 CNR1 (1.00) CNR1
SCHEMBL4813964 0.75 CNR1 (1.00) CNR1ADRB2ADRA2AAGTR1GLP1R
SCHEMBL4823379 0.74 CNR1 (0.79) CNR1
SCHEMBL4813072 0.73 CNR1 (1.00) CNR1
SCHEMBL6507282 0.73 CNR1 (0.57) CNR1
SCHEMBL4821388 0.72 CNR1 (0.74) CNR1
SCHEMBL4715368 0.71 CNR1 (0.64) CNR1ADRB2ADRA2AAGTR1GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005061504-A1 BICYCLIC PYRIDAZINONE CANNABINOID RECEPTOR LIGANDS AND USES THEREOF PFIZER PRODUCTS INC. (US) 2005-07-07 WO claimed
WO-2005061504-A1 BICYCLIC PYRIDAZINONE CANNABINOID RECEPTOR LIGANDS AND USES THEREOF PFIZER PRODUCTS INC. (US) 2005-07-07 WO disclosed
WO-2005061504-A1 BICYCLIC PYRIDAZINONE CANNABINOID RECEPTOR LIGANDS AND USES THEREOF PFIZER PRODUCTS INC. (US) 2005-07-07 WO disclosed