SCHEMBL650646

SCHEMBL650646

CCCCCCCCOC(=O)OC(c1ccc(S(C)(=O)=O)cc1)C(CF)NC(=O)C(Cl)Cl

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.56
MEN1 O00255 1/20 0.56
CYP3A4 P08684 1/20 0.56
KMT2A Q03164 1/20 0.56
TSHR P16473 1/20 0.47
MAPT P10636 1/20 0.40
PLA2G2C Q5R387 1/20 0.35
TRPV1 Q8NER1 6/20 0.34
HTT P42858 1/20 0.34
CA12 O43570 3/20 0.33
CA1 P00915 3/20 0.33
CA2 P00918 3/20 0.33
CA9 Q16790 3/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL651749 1.00 LMNA (0.56) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL650645 1.00 LMNA (0.56) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL650603 1.00 LMNA (0.56) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL651550 1.00 LMNA (0.56) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL651551 1.00 LMNA (0.56) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL10124445 0.95 CYP3A4 (0.61) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL648812 0.92 CYP3A4 (0.60) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL652244 0.91 CYP3A4 (0.64) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL648316 0.91 LMNA (0.54) LMNAMEN1CYP3A4KMT2ATSHR
SCHEMBL648315 0.91 LMNA (0.54) LMNAMEN1CYP3A4KMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119667-B2 Carbonates of fenicol antibiotics SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) 2012-02-21 US claimed
EP-1966129-B1 CARBONATES OF FENICOL ANTIBIOTICS SCHERING PLOUGH LTD (CH) 2011-08-17 EP claimed
US-8119667-B2 Carbonates of fenicol antibiotics SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) 2012-02-21 US disclosed
EP-1966129-B1 CARBONATES OF FENICOL ANTIBIOTICS SCHERING PLOUGH LTD (CH) 2011-08-17 EP disclosed
US-20070155799-A1 CARBONATES OF FENICOL ANTIBIOTICS INTERVET INC. 2007-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070155799-A1 CARBONATES OF FENICOL ANTIBIOTICS CYP4F3, TET1, CYP4F2 LMNA 2548/4885MEN1 1940/4885CYP3A4 28/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.