Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.81 |
| ▸ | PDE6D | O43924 | 4/20 | 0.66 |
| ▸ | PDE6A | P16499 | 4/20 | 0.66 |
| ▸ | PDE6G | P18545 | 4/20 | 0.66 |
| ▸ | PDE6B | P35913 | 4/20 | 0.66 |
| ▸ | PDE6C | P51160 | 4/20 | 0.66 |
| ▸ | PDE6H | Q13956 | 4/20 | 0.66 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.66 |
| ▸ | ACHE | P22303 | 4/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689505 | 0.90 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7442714 | 0.90 | PDE5A (0.91) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7689509 | 0.90 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7449046 | 0.90 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6503330 | 0.88 | PDE5A (0.85) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6499296 | 0.87 | PDE5A (0.73) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6504928 | 0.86 | PDE5A (0.82) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6505507 | 0.85 | PDE5A (0.77) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2851411 | 0.85 | PDE5A (0.88) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6783325 | 0.85 | PDE5A (0.88) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6911542-B2 | Pyrazino[1′,2′:1,6]pyrido[3,4b]indole derivatives | LILLY ICOS LLC. (US) | 2005-06-28 | — | — | US | claimed |
| US-20030225094-A1 | Chemical compounds | ICOS CORPORATION | 2003-12-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225094-A1 | Chemical compounds | ABCG2, SDHA, CYP11B1 | PDE5A 2160/4885PDE6D 1716/4885PDE6A 2779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.