Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027001 | 0.81 | IDO1 (0.55) | KMOADORA2AADORA1IDO1MAP4K4 | |
| SCHEMBL4402505 | 0.80 | CCR1 (0.58) | MAPK14KMONISCHIDO1RAB9A | |
| SCHEMBL14770762 | 0.80 | IDO1 (0.44) | MAPK14IDO1 | |
| SCHEMBL11992043 | 0.80 | UHRF1 (0.58) | MAPK14KMONISCHRAB9AMAP4K4 | |
| SCHEMBL2329610 | 0.79 | ADORA2A (0.56) | ADORA2AADORA1IDO1CYP19A1 | |
| SCHEMBL29461217 | 0.79 | ADORA2A (0.56) | ADORA2AADORA1IDO1CYP19A1 | |
| SCHEMBL5788570 | 0.79 | MAPK14 (0.53) | MAPK14ADORA2AADORA1RAB9ANPC1 | |
| SCHEMBL25070215 | 0.78 | ADORA2A (0.54) | ADORA2AADORA1IDO1CYP19A1 | |
| SCHEMBL14154863 | 0.77 | BIRC5 (0.45) | MAPK14ADORA2AADORA1IDO1RAB9A | |
| SCHEMBL31337817 | 0.77 | SRC (0.48) | MAPK14ADORA2AADORA1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005020987-A1 | HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSES GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-03-10 | — | — | WO | disclosed |
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |