Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1052265 | 0.84 | POLB (0.40) | POLBALDH1A1TSHRGAACYP3A4 | |
| SCHEMBL1594230 | 0.73 | ALDH1A1 (0.42) | POLBALDH1A1TSHRGAACYP3A4 | |
| SCHEMBL8532180 | 0.73 | POLB (0.40) | POLBALDH1A1TSHRGAACYP3A4 | |
| SCHEMBL6922463 | 0.73 | GAA (0.40) | POLBALDH1A1TSHRGAACYP3A4 | |
| SCHEMBL5100575 | 0.72 | CYP3A4 (0.41) | POLBTSHRGAACYP3A4CYP2C9 | |
| SCHEMBL7718920 | 0.72 | POLB (0.39) | POLBALDH1A1TSHRGAACYP3A4 | |
| SCHEMBL10108 | 0.71 | GAA (0.40) | POLBALDH1A1TSHRGAACYP3A4 | |
| SCHEMBL14524858 | 0.70 | POLB (0.38) | POLBALDH1A1TSHRGAACYP3A4 | |
| SCHEMBL1051880 | 0.70 | POLB (0.53) | POLBALDH1A1TSHRGAACYP3A4 | |
| SCHEMBL9461450 | 0.69 | ALDH1A1 (0.54) | POLBALDH1A1TSHRGAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |