Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 13/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505865 | 0.89 | IKBKB (0.58) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6507636 | 0.86 | IKBKB (0.51) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6532445 | 0.86 | IKBKB (0.44) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6505484 | 0.84 | CHEK1 (0.55) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL6505745 | 0.81 | IKBKB (0.57) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL14204814 | 0.79 | IKBKB (0.55) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL5139231 | 0.79 | IKBKB (0.55) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL491042 | 0.79 | IKBKB (0.55) | IKBKBJAK2JAK3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6510283 | 0.79 | IKBKB (0.55) | IKBKBJAK2JAK3MEN1KMT2A | |
| SCHEMBL11921318 | 0.79 | IKBKB (0.59) | IKBKBJAK2JAK3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |
| WO-2005047236-A1 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2005-05-26 | — | — | WO | disclosed |
| EP-1366024-A2 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | Esperion Therapeutics Inc. (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002030882-A2 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2002-04-18 | — | — | WO | disclosed |