Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.55 |
| ▸ | IKBKB | O14920 | 9/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505865 | 0.85 | IKBKB (0.58) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL6507152 | 0.84 | IKBKB (0.57) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL6514837 | 0.81 | CHEK1 (0.47) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL6507636 | 0.79 | IKBKB (0.51) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL11921318 | 0.76 | IKBKB (0.59) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL6506816 | 0.76 | CHEK1 (0.36) | CHEK1IKBKBALDH1A1 | |
| SCHEMBL6511724 | 0.75 | MAPT (0.51) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL1563630 | 0.74 | CHEK1 (0.45) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL6505745 | 0.74 | IKBKB (0.57) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL6510409 | 0.73 | CHEK1 (0.44) | CHEK1IKBKBJAK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |