Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510633 | 0.82 | MEN1 (0.48) | CHEK1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6512362 | 0.77 | IKBKB (0.57) | MAPTMEN1KMT2ARAB9AGAA | |
| SCHEMBL1926828 | 0.77 | CHEK1 (1.00) | CHEK1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6506340 | 0.76 | FLT3 (0.51) | KDM4EMAPTMEN1KMT2AHPGD | |
| SCHEMBL1928372 | 0.76 | CHEK1 (0.98) | CHEK1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6530168 | 0.75 | IKBKB (0.62) | CHEK1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL1397213 | 0.75 | CYP2D6 (0.75) | CYP2D6CYP2C9HIF1AKDM4EGAA | |
| SCHEMBL6507704 | 0.74 | CHEK1 (0.49) | CHEK1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6510003 | 0.74 | P2RX1 (0.52) | MAPTMEN1KMT2ARAB9AHTT | |
| SCHEMBL6583311 | 0.74 | CYP2D6 (0.68) | CYP2D6CYP2C9HIF1AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |