Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506340 | 0.86 | FLT3 (0.51) | IKBKBMEN1KMT2AJAK2HDAC6 | |
| SCHEMBL6509110 | 0.85 | IKBKB (0.63) | IKBKBMEN1KMT2AJAK2HDAC6 | |
| SCHEMBL6530168 | 0.85 | IKBKB (0.62) | IKBKBMEN1KMT2AJAK2HDAC6 | |
| SCHEMBL6507704 | 0.84 | CHEK1 (0.49) | IKBKBMEN1KMT2AJAK2HDAC6 | |
| SCHEMBL6510003 | 0.84 | P2RX1 (0.52) | IKBKBMEN1KMT2AJAK2JAK3 | |
| SCHEMBL6510633 | 0.83 | MEN1 (0.48) | IKBKBMEN1KMT2AJAK2HDAC6 | |
| SCHEMBL6510833 | 0.83 | IKBKB (0.53) | IKBKBMEN1KMT2AJAK2HDAC6 | |
| SCHEMBL6514964 | 0.83 | CHEK1 (0.57) | IKBKBMEN1KMT2ATDP1PARP1 | |
| SCHEMBL6507728 | 0.81 | IKBKB (0.50) | IKBKBMEN1KMT2AJAK2HDAC6 | |
| SCHEMBL6503111 | 0.80 | MAPK8 (0.67) | IKBKBMEN1KMT2AJAK2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |